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(R,S)-N-Nitroso Anabasine
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(R,S)-N-Nitroso Anabasine

(R,S)-N-Nitroso Anabasine

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CAT NO

AQ-N000427
CAS NO

NA
Mol.F

C10H13N3O : HCl
Mol.Wt

191.2 : 36.5
Availability

Instock
Chemical Name

3-(1-nitrosopiperidin-2-yl)pyridine hydrochloride
Synonym

N-Nitrosoanabasine HCl
Rel. CAS No

37620-20-5 (free base)

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(R,S)-N-Nitroso Anabasine


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Product Description

(R,S)-N-Nitroso Anabasine is a high-quality reference standard supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines. This product is essential for analytical method development, method validation (AMV), quality control (QC) applications, and plays a crucial role in Abbreviated New Drug Applications (ANDA).

(R,S)-N-Nitroso Anabasine can be used as a reference standard, with possible traceability to pharmacopeial standards such as USP or EP, based on feasibility. AquigenBio products are strictly for analytical purposes and is not intended for human use.

Applications of (R,S)-N-Nitroso Anabasine:

  1. Tobacco-Specific Nitrosamine (TSNA) Research:
    (R,S)-N-Nitroso Anabasine is a known TSNA and is widely used in research related to tobacco product safety, exposure analysis, and toxicological assessment. It serves as a marker compound in the evaluation of smokeless and combustible tobacco products.

  2. Toxicology & Carcinogenicity Studies:
    Employed in carcinogenicity and genotoxicity testing to study its biological impact and the potential cancer-causing mechanisms associated with nitrosamine exposure in tobacco users.

  3. Analytical Method Development:
    Used as a reference standard for developing and validating sensitive analytical methods (e.g., LC-MS/MS, GC-MS) to detect trace levels of nitrosamines in tobacco and biological matrices.

  4. Regulatory & Quality Control Testing:
    Supports regulatory compliance with organizations such as the FDA, WHO, and ISO by helping manufacturers and labs monitor and limit TSNA content in tobacco and nicotine products.

  5. Exposure and Biomarker Studies:
    Utilized in human biomonitoring studies to trace and quantify exposure levels in biological samples such as urine, blood, or saliva, especially in risk-based public health evaluations.

  6. Research in Nicotine Alkaloid Derivatives:
    Serves as a key compound in R&D projects studying the nitrosation of minor tobacco alkaloids and their implications in product formulation and safety.

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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