Medicinal Chemistry & Drug Discovery

Understanding Medicinal Chemistry & Drug Discovery

Medicinal Chemistry is the field of scientific exploration focused on the design and discovery of new chemical compounds with therapeutic capabilities, along with their progression into beneficial medications. It encompasses the generation and fine-tuning of molecules with the goal to construct or enhance novel medicinal drugs for combating specific conditions. Drug discovery, on the other hand, signifies the mechanism through which new potential compounds are identified to serve as efficacious medications. This case entails a multifaceted sphere rooted in diverse foundational disciplines like organic chemistry, biology, and pharmacology.

New Chemical Entity (NCE)

A New Chemical Entity (NCE) refers to a medication featuring an active component that hasn’t been previously approved by the United States Food and Drug Administration (USFDA) in any other application. An NCE is typically developed by innovator drug manufacturers during the initial phase of the product development cycle. This NCE later undergoes a series of clinical trials with the aim of becoming a marketable pharmaceutical product.

“Developing and launching a new drug typically involves a time frame of 10-15 years and a financial investment exceeding $1 billion. Medicinal chemistry is pivotal in this extensive process.”

Unlocking the Potential of Medicines


Unlocking the Potential of Medicines

Modern Drug Discovery

Modern Drug Discovery encompasses the recognition of screening hits and the utilization of medicinal chemistry to enhance these hits. The optimization focuses on increasing the compound’s affinity, selectivity (to lessen the likelihood of side effects), efficiency/potency, metabolic stability (for an extended half-life), and oral bioavailability. The drug development process proceeds once a compound meeting all these criteria is identified. If successful, it then transition into the stage of clinical trials.

The possible impurities during the synthetic process of a therapeutic peptide include the following:



Insertion can lead to an addition of extra amino acids in the peptide chain, affecting the desired structure, function, and interaction of the synthesized peptide causing potential complications in the therapeutic uses.


Deletion Sequence

During peptide synthesis, the deletion sequences result in missing amino acids altering the bioactivity of the peptide, impacting the overall effectiveness or safety of the peptide-based therapeutic.


Modification Sequences

Impurities might occur from unintended side reactions, modifying the original sequence. These sequence modifications can affect the therapeutic peptide's stability, binding ability, and pharmacokinetic properties.


Incomplete Deprotection Sequences

Incomplete deprotection sequences result in residual protecting groups on the peptide, which can interfere with its intended biological activity and reduce pharmaceutical efficiency.



Racemization can cause chiral inversion of amino acids, altering the peptide configuration. This may affect the binding configurations, reducing the therapeutic efficacy, and even lead to undesired side effects.


Purification Methods or SPPS

Inaccuracies in purification processes or SPPS can lead to the presence of by-products and unreacted reagents, compromising the purity and potency of the final therapeutic peptide.

FAQs About Medicinal Chemistry

What are the 4 Stages of Drug Discovery?

The process of drug discovery is a structured and intricate one, often divided into distinct steps for effective execution. These stages allow for a ystematic validation and development of potential therapeutic drugs, which are outlined below:

  • Early Drug Discovery
  • Pre-Clinical Phase
  • Clinical Phases
  • Regulatory Approval

Synthetic Capabilities of Aquigen Bio Sciences

Aquigen Bio Sciences boasts advanced synthetic capabilities, equipping the team to tackle complex pharmaceutical challenges. Our expertise lies in synthesizing intricate molecules, ensuring efficiency while maintaining the highest quality in the drug discovery process.

  • Complex molecules from milligram to multigram
  • Reference compounds and scaffold synthesis
  • Small molecules; Analogues for lead generation; Lead optimization
  • Focused Libraries: 50-100
  • Large Libraries: >500
  • Multi-step stereoselective synthesis of chiral molecules
  • Expertise in handling photo-chemical reactions
  • Chemoenzymatic and resolution techniques for chiral molecules
  • Metabolite synthesis

Why choose Aquigen Bio Science for Medicinal Chemistry?

Aquigen Bio Science provides early-stage drug discovery chemistry services. This domain is a collaborative effort where scientists work together to effectively evaluate hits, optimize compounds, and provide high-quality candidates during the hit-to-lead and lead optimization stages of drug discovery. Our team of scientists are proficient in medicinal chemistry, which engages with the discovery, development, identification, and comprehension of the operational mechanism of biologically active compounds at a molecular level. Get in touch with us for a customized quote today!
Shopping Cart
Scroll to Top


Click one of our contacts below to chat on WhatsApp