CAT NO	AQ-C019709
CAS NO	2468-21-5
Mol.F	C21H24N2O2
Mol.Wt	336.4
Availability	yes
Chemical name	(6R, 6aR, 11R)-methyl 7-ethyl-6, 6a, 9, 10, 12, 13-hexahydro-5H-6, 9-methanopyrido[1', 2':1, 2]azepino[4, 5-b]indole-6-carboxylate

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Product Description

Catharanthine is a high-quality reference standard supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines. This product is essential for analytical method development, method validation (AMV), quality control (QC) applications, and plays a crucial role in Abbreviated New Drug Applications (ANDA).
Catharanthine can be used as a reference standard, with possible traceability to pharmacopeial standards such as USP or EP, based on feasibility. AquigenBio products are strictly for analytical purposes and is not intended for human use.

More Info:

Catharanthine is a naturally occurring monoterpenoid indole alkaloid primarily isolated from the plant Catharanthus roseus (commonly known as Madagascar periwinkle). It is one of several alkaloids biosynthesized in this plant and plays a key intermediate role in the production of clinically important anti-cancer compounds.

Biosynthesis and Role

Catharanthine is derived biosynthetically from strictosidine, a key intermediate in the monoterpene indole alkaloid biosynthetic pathway. In Catharanthus roseus, catharanthine is enzymatically coupled with vindoline to produce vinblastine and vincristine, two potent anticancer agents used in chemotherapy.

Key Enzyme Involvement:

Strictosidine synthase (precursor formation)
Catharanthine synthase
Peroxidase (for vinblastine coupling with vindoline)

Chemical Properties

Solubility: Slightly soluble in water; soluble in organic solvents like methanol and chloroform
Melting Point: 250–260 °C (decomposes)
Stability: Sensitive to light and air; should be stored under inert conditions

Applications and Uses

While catharanthine itself is not used directly in pharmaceuticals, its most critical application is as a biosynthetic precursor for the semi-synthesis of:

Vinblastine
Vincristine

These are dimeric indole alkaloids with significant applications in cancer treatment (e.g., leukemia, lymphoma, Hodgkin’s disease).

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Catharanthine