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Benazepril HCl d5

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CAT NO

AQ-B002624

CAS NO

1279026-26-4

Mol.F

C24H23D5N2O5 : HCl

Mol.Wt

429.5 : 36.5

Availability

Custom Synthesis

Chemical name

2-((S)-3-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)amino)-2-oxo-2, 3, 4, 5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid hydrochloride

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Benazepril HCl d5


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Product Description

Benazepril HCl d5 is a high-quality reference standard supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines. This product is essential for analytical method development, method validation (AMV), quality control (QC) applications, and plays a crucial role in Abbreviated New Drug Applications (ANDA).

Benazepril HCl d5 can be used as a reference standard, with possible traceability to pharmacopeial standards such as USP or EP, based on feasibility. AquigenBio products are strictly for analytical purposes and is not intended for human use.

Applications of Benazepril HCl D5

1. Internal Standard in LC-MS/MS Analysis
Benazepril HCl D5 is a deuterated analog used as an internal standard in liquid chromatography–mass spectrometry (LC-MS/MS) to ensure accurate quantification of benazepril in biological samples like plasma or serum.

2. Bioanalytical Method Validation
Supports validation of bioanalytical methods for pharmacokinetic (PK), bioavailability (BA), and bioequivalence (BE) studies by correcting variability in sample processing and instrument response.

3. Drug Metabolism & Pharmacokinetics (DMPK) Studies
Enables precise monitoring of benazepril metabolism, absorption, and elimination in preclinical and clinical trials.

4. Therapeutic Drug Monitoring (TDM)
Useful in labs conducting TDM assays for benazepril in patients undergoing treatment for hypertension or heart failure.

5. Stability & Recovery Studies
Used to assess sample stability and recovery rates during analytical procedure development and validation, especially in complex biological matrices.

6. Research in Isotope Dilution Techniques
Ideal for isotope dilution experiments where highly accurate quantification is required, minimizing matrix effects.

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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