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Belumosudil Mesylate
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Belumosudil Mesylate

Belumosudil Mesylate

Available on backorder

Make a Quick Enquiry ↴
CAT NO

AQ-B001512
CAS NO

2109704-99-4
Mol.F

C26H24N6O2 : CH4O3S
Mol.Wt

452.5 : 96.1
Availability

Custom Synthesis
Chemical name

2-(3-(4-((1H-indazol-5-yl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide methanesulfonate

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Belumosudil Mesylate


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Product Description

Belumosudil Mesylate is a high-quality reference standard supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines. This product is essential for analytical method development, method validation (AMV), quality control (QC) applications, and plays a crucial role in Abbreviated New Drug Applications (ANDA).

Belumosudil Mesylate can be used as a reference standard, with possible traceability to pharmacopeial standards such as USP or EP, based on feasibility. AquigenBio products are strictly for analytical purposes and is not intended for human use.

Applications of Belumosudil Mesylate:

1. Treatment of Chronic Graft-versus-Host Disease (cGVHD)

  • Belumosudil Mesylate is the mesylate salt form of Belumosudil, a selective ROCK2 inhibitor.

  • Approved by the U.S. FDA for treating chronic GVHD in patients who have failed at least two prior lines of systemic therapy.

  • Modulates immune response and reduces tissue inflammation and fibrosis.

2. Immunomodulatory Research

  • Plays a key role in the research of immune system regulation.

  • Inhibits Rho-associated coiled-coil-containing protein kinase 2 (ROCK2), affecting:

    • T-cell activation

    • Cytokine production (e.g., IL-17, IL-21, IFN-γ)

  • Explored in autoimmune and inflammatory disease models.

3. Fibrosis and Anti-inflammatory Studies

  • Investigated for its potential in treating organ fibrosis, including:

    • Lung fibrosis

    • Liver fibrosis

    • Kidney inflammation

  • Its anti-fibrotic and anti-inflammatory actions make it valuable for preclinical and translational studies.

4. Pharmaceutical API Standard

  • Used as a reference standard in drug development and manufacturing:

    • Assay development

    • Stability testing

    • Impurity profiling

    • Pharmacokinetic and bioequivalence studies

5. Oncology and Hematology Research

  • Under evaluation for potential use in hematological malignancies and solid tumors, due to its immune pathway modulation.

  • Supports clinical and preclinical studies related to:

    • Tumor microenvironment

    • T-cell exhaustion reversal

6. Drug Formulation and Quality Control

  • Used in the development of oral formulations for Belumosudil-based therapeutics.

  • Essential in:

    • Quality control testing

    • Batch release of final products

    • Formulation stability studies

⚠️ Note: Belumosudil Mesylate is a regulated pharmaceutical API. It should be handled by qualified professionals and is intended for therapeutic use under medical supervision or research applications in compliance with regulatory standards.

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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