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Azithromycin EP Impurity H

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Cat No

AQ-A003517

Cas No

612069-30-4

Mol.F

C45H77N3O15S

Mol.Wt

932.17

Availability

yes

Chemical name

N-(4-(N-((2S, 3R, 4S, 6R)-2-(((2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)-2-ethyl-3, 4, 10-trihydroxy-13-(((2R, 4R, 5S, 6S)-5-hydroxy-4-methoxy-4, 6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3, 5, 6, 8, 10, 12, 14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl)oxy)-3-hydroxy-

Packing

Product will be supplied in Vials, in certain conditions we also use ‘Septa Vials’

Controlled

No

Parent API

Abacavir

Purity

Not less than 90%

Therapeutic

Not less than 90%

Isotopic Enrichment

Antiretroviral / Anti-HIV

Smileys

Not less than 95%

Canonical Smiles

C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO

InchIKey

C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO

Inchl

MCGSCOLBFJQGHM-ZOTQTBSBSA-N

IUPAC

InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1/i2D2,3D2

Hazardous

[(1S,4R)-4-[2-amino-6-[(2,2,3,3-tetradeuteriocyclopropyl)amino]purin-9-yl]cyclopent-2-en-1-yl]methanol

Azithromycin EP Impurity H

Cat No

AQ-A003517

Cas No

612069-30-4

Mol.F

C45H77N3O15S

Mol.Wt

932.17

Availability

yes

Chemical name

N-(4-(N-((2S, 3R, 4S, 6R)-2-(((2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)-2-ethyl-3, 4, 10-trihydroxy-13-(((2R, 4R, 5S, 6S)-5-hydroxy-4-methoxy-4, 6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3, 5, 6, 8, 10, 12, 14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl)oxy)-3-hydroxy-

Packing

Product will be supplied in Vials, in certain conditions we also use ‘Septa Vials’

Controlled

No

Parent API

Abacavir

Purity

Not less than 90%

Therapeutic

Not less than 90%

Isotopic Enrichment

Antiretroviral / Anti-HIV

Smileys

Not less than 95%

Canonical Smiles

C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO

InchIKey

C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO

Inchl

MCGSCOLBFJQGHM-ZOTQTBSBSA-N

IUPAC

InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1/i2D2,3D2

Hazardous

[(1S,4R)-4-[2-amino-6-[(2,2,3,3-tetradeuteriocyclopropyl)amino]purin-9-yl]cyclopent-2-en-1-yl]methanol

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Azithromycin EP Impurity H


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Product Description

Abacavir D4 is a deuterated analog of Abacavir, an antiretroviral drug used in the treatment of HIV and AIDS. Deuterated compounds are similar to their non-deuterated counterparts, but with the substitution of hydrogen atoms with heavier deuterium atoms, which can provide unique advantages in drug development. Abacavir D4 is used in combination with other antiretroviral drugs to treat HIV-1 infection in adults and children. It works by inhibiting the activity of the reverse transcriptase enzyme, which is necessary for the replication of the virus. This prevents the virus from multiplying, reducing the amount of virus in the body and slowing down the progression of the disease. In terms of chemical information, Abacavir D4 has a molecular formula of C14H11D4N5O and a molecular weight of 280.36 g/mol. Its physical properties include a melting point range of 203-208�C and a solubility of 15 mg/mL in water. Abacavir D4 is generally well-tolerated, with common side effects including headache, fatigue, nausea, and diarrhea. However, in rare cases, it can cause severe allergic reactions, which can be life-threatening. Patients are advised to seek medical attention immediately if they experience symptoms such as fever, rash, or difficulty breathing.
In conclusion, Abacavir D4 is an important antiretroviral drug in the treatment of HIV and AIDS. Its deuterated form offers potential advantages in terms of pharmacokinetics and pharmacodynamics, and it is generally well-tolerated by patients. However, as with all medications, it should be used only under the guidance of a healthcare professional.

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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