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(6S)-Tetrahydrofolic Acid

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CAT NO

AQ-F006117

CAS NO

71963-69-4

Mol.F

C19H23N7O6

Mol.Wt

445.4

Availability

Custom Synthesis

Chemical name

(4-((((S)-2-amino-4-oxo-1, 4, 5, 6, 7, 8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

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(6S)-Tetrahydrofolic Acid


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Product Description

(6S)-Tetrahydrofolic Acid is a high-quality reference standard supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines. This product is essential for analytical method development, method validation (AMV), quality control (QC) applications, and plays a crucial role in Abbreviated New Drug Applications (ANDA).

(6S)-Tetrahydrofolic Acid can be used as a reference standard, with possible traceability to pharmacopeial standards such as USP or EP, based on feasibility. AquigenBio products are strictly for analytical purposes and is not intended for human use.

Applications of (6S)-Tetrahydrofolic Acid:

  1. Active Folate Form in Biochemistry

    • (6S)-Tetrahydrofolic Acid is the biologically active form of folate involved in numerous one-carbon transfer reactions essential for DNA synthesis, repair, and methylation.

  2. Pharmaceutical Development

    • Used in the formulation of folate-based supplements or therapeutics, particularly in treating folate deficiency, anemia, and in prenatal care to support fetal development.

  3. Cancer and Chemotherapy Research

    • Studied for its role in modulating the efficacy and toxicity of antifolate drugs (e.g., methotrexate), which target folate metabolism in cancer cells.

  4. Cell Culture & Metabolic Studies

    • Used as a cofactor in cell culture media and metabolic assays, especially in research related to nucleotide biosynthesis and amino acid metabolism.

  5. Neurodevelopmental & Neuropsychiatric Applications

    • Investigated in the treatment of neurological disorders and developmental conditions where folate metabolism is impaired, such as autism spectrum disorders and depression.

  6. Nutritional and Clinical Diagnostics

    • Applied in nutritional studies and diagnostic testing to evaluate folate status in the body, helping assess risk for neural tube defects and cardiovascular conditions.

  7. Genetic and Enzymatic Research

    • Used in studies involving folate cycle enzymes like MTHFR and DHFR to understand genetic mutations and their impact on folate metabolism and related diseases.

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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