AquigenBio

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(2S)-N’-Nitrosonornicotine
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(2S)-N’-Nitrosonornicotine

(2S)-N’-Nitrosonornicotine

Available on backorder

Make a Quick Enquiry ↴
CAT NO

AQ-N000381
Mol.S

O=NN1[C@H](C2=CN=CC=C2)CCC1
Availability

Custom Synthesis
Mol.Wt

177.2
Chemical Name

(S)-3-(1-nitrosopyrrolidin-2-yl)pyridine

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Available on backorder

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(2S)-N’-Nitrosonornicotine


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  • Complete Documentation
  • Worldwide Delivery
  • Product Accuracy
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Product Description

(2S)-N’-Nitrosonornicotine is a high-quality reference standard supplied with comprehensive characterization data, ensuring compliance with regulatory guidelines. This product is essential for analytical method development, method validation (AMV), quality control (QC) applications, and plays a crucial role in Abbreviated New Drug Applications (ANDA).

(2S)-N’-Nitrosonornicotine can be used as a reference standard, with possible traceability to pharmacopeial standards such as USP or EP, based on feasibility. AquigenBio products are strictly for analytical purposes and is not intended for human use.

Applications of (2S)-N’-Nitrosonornicotine:

  1. Tobacco-Specific Nitrosamine (TSNA) Research:
    (2S)-N’-Nitrosonornicotine is a well-known TSNA and is extensively studied in research related to tobacco product analysis, toxicology, and public health impact.

  2. Carcinogenicity and Toxicological Studies:
    Used as a reference compound in evaluating the carcinogenic potential of tobacco-related nitrosamines. It plays a key role in understanding exposure risks in both smokers and users of smokeless tobacco.

  3. Regulatory and Compliance Testing:
    Assists laboratories and regulatory agencies in monitoring TSNA levels in tobacco products, contributing to compliance with FDA, WHO, and ISO guidelines on tobacco safety.

  4. Analytical Method Development:
    Employed in the development and validation of sensitive analytical techniques (e.g., LC-MS/MS, GC-MS) for detecting TSNAs in complex matrices such as tobacco, e-liquids, or biological samples.

  5. Biomarker and Exposure Studies:
    Used in biomonitoring studies to measure TSNA exposure in humans by detecting this compound or its metabolites in urine, saliva, or blood.

  6. Cancer Research and Risk Assessment:
    Supports investigations in oncology and molecular biology by serving as a model compound for DNA adduct formation, aiding in understanding mechanisms of TSNA-induced carcinogenesis.

Safety & Handling Information for Chemical Products

1. Read the Safety Data Sheet (SDS) : The SDS contains important safety information for handling procedures, first-aid measures, disposal instructions, etc. Read it carefully.

2. Wear Personal Protective Equipment (PPE) : Always wear PPE as indicated in the SDS and by the manufacturer. This may include safety goggles, gloves, lab coats, respirators, and protective clothing.

3. Handle with Care : Be careful with chemical products - prevent spills, splashes, or inhaling fumes or dust. Use secondary trays or spill kits during chemical transfer or dispensing.

4. Work in a Well-Ventilated Area : Use chemical products in well-ventilated spaces to reduce vapour or gas exposure. Indoors, ensure ample ventilation via mechanical systems, fume hoods, or open windows and doors.

5. Avoid Mixing Chemicals : Avoid mixing chemical products unless directed by the manufacturer or a qualified professional. Incompatible mixes can lead to hazardous reactions, toxic gas releases, or explosions.

6. Labeling and Storage : Label chemical containers with product names, hazards, and handling information. Store in original or approved containers.

7. Prevent Contamination : Prevent cross-contamination with dedicated equipment or thorough decontamination. Keep food, drinks, and personal items away from chemical storage or work zones.

8. Emergency Procedures : Learn emergency procedures for spills, leaks, fires, or exposure incidents. Keep spill control materials, fire extinguishers, and emergency eyewash/shower facilities accessible.

9. First Aid : Know first aid for chemical exposure (eye contact, skin contact, inhalation, and ingestion). Ensure accessible supplies and trained personnel for assistance.

10. Proper Waste Disposal : Ensure chemical waste disposal as per local regulations; segregate hazardous from non-hazardous waste for health and environmental protection.

11. Training and Education : Offer thorough training to chemical handlers, covering usage, hazards, safety, and emergency response.

12. Report Incidents and Near Misses : Report incidents, near misses, spills, or safety concerns promptly to authorities and supervisors for investigation and action. By following these safety and handling guidelines, you can minimize risks associated with chemical products and create a safer work environment for yourself and others.

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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

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