Quetiapine is an atypical antipsychotic medication that is commonly used to treat mental health conditions such as schizophrenia, bipolar disorder and major depressive disorder. It works by helping to restore the balance of certain natural chemicals in the brain called neurotransmitters. Being one of the leading Deuterated Compounds Suppliers, Aquigen Bio Sciences Team actively deals with Quetiapine. In this blog, we will discuss in detail Quetiapine, atypical antipsychotic drug- how it works, its uses, side effects and important safety information.

Quetiapine was first approved by the U.S. Food and Drug Administration (FDA) in 1997 under the brand name Seroquel for the treatment of schizophrenia and bipolar disorder. It is available generically and under several other brand names. According to clinical studies, Quetiapine is effective in relieving the symptoms of schizophrenia like hallucinations and delusions. It is also effective in controlling mood swings and manic episodes associated with bipolar disorder.

How does Quetiapine Work?

Quetiapine belongs to a class of medications called atypical antipsychotics. It is thought to work by blocking the effects of dopamine and serotonin – two important chemicals (also known as neurotransmitters) in the brain. The exact method is still unknown, but it is believed that an imbalance of these neurotransmitters may contribute to psychiatric disorders. By blocking the dopamine and serotonin receptors in the brain, quetiapine helps to restore the balance of these neurotransmitters, thus improving the symptoms.

Uses of Quetiapine

The primary uses of Quetiapine include:

  • Schizophrenia: It is effective in treating the positive symptoms (hallucinations, delusions, disorganized speech and behaviour etc.) of schizophrenia.
  • Bipolar disorder: Quetiapine is used to treat the manic and depressive episodes associated with bipolar I disorder. It is also used as a maintenance therapy to help reduce the risk of recurrence of manic or depressive episodes.
  • Major depression: It is used along with an antidepressant to treat major depressive disorder in adults whose condition has not improved with antidepressant treatment alone.
  • Other uses: Quetiapine is also used off-label for conditions like generalized anxiety disorder, insomnia, dementia and psychosis associated with Parkinson’s disease. It may help improve the symptoms along with the standard treatment.

Side Effects of Quetiapine

Like all medications, quetiapine can cause some side effects. Some of the most common side effects include:

  • Drowsiness, dizziness
  • Dry mouth
  • Increased appetite and weight gain
  • Constipation
  • Headache
  • Nausea
  • Fatigue

These side effects usually tend to fade away over time as the body adjusts to the medication. Some serious but rare side effects include diabetes, high cholesterol and high triglycerides which need monitoring. It is important to consult your doctor if any serious side effects occur.

Special Precautions with Quetiapine

Some key safety precautions to take with quetiapine treatment include:

  • Information of the complete medical history including any allergies/sensitivities is a must.
  • Caution if the patient has heart disease, glaucoma or problems with liver or kidney function.
  • Know about all the medications the patient is taking including herbal supplements to avoid drug interactions.
  • Limited alcohol use as it can worsen the side effects.
  • Use caution while driving or operating heavy machines as it may cause drowsiness initially.
  • Monitor for worsening depression/suicidal thoughts, especially in the initial phase.
  • Regular medical check-ups to monitor for side effects like changes in weight, blood pressure, sugar and lipid levels.


In conclusion, quetiapine is an important psychiatric medication, which is used effectively to treat a variety of mental health conditions like schizophrenia, bipolar disorder and major depression. It has proven efficacy in managing the symptoms along with relatively milder side effects as compared to typical antipsychotics. Proper precautions, monitoring and healthcare provider guidance are important while on treatment with quetiapine.

Aquigen Bio Sciences is a leading Deuterated compound supplier that are used in the early stages of drug discovery and development. We undertake custom synthesis projects including Deuterated Isotopes that are used for investigating drug metabolism and for developing drug candidates. Our expertise in synthetic chemistry and focus on quality can help accelerate pharmaceutical research. Please feel free to contact us to further discuss your research needs for quetiapine and how we can support you.

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